A 2-week guided journey from Rome to Palermo showcases Southern Italy and Sicily’s highlights, combining scenic days and expert-led visits with memorable regional dining. Stay in hotels across Italy: Radisson Blu GHR in Rome (2 nights), Hotel Isabella in Sorrento (2), Grand Hotel La Chiusa di Chietri in Alberobello (3), UNAHOTELS MH Matera (1), Hellenia Yachting in Giardini Naxos (3), and Federico II Central Palace in Palermo (2).