An 18-day journey from Cusco to Rio blends Machu Picchu by train, an Amazon jungle lodge, cosmopolitan Buenos Aires and powerful Iguassu Falls. Stay in hotels and lodges throughout, including Mamasara in Cusco, Tunupa Lodge in Ollantaytambo, Flower’s House in Aguas Calientes, and Corto Maltes Amazonia Lodge with open-walled rooms. Overnight in Lima at Ibis Budget Miraflores, then M Concept Hotel, Pietro Angelo Hotel, and Ibis Copacabana in Rio.